Younger Fathers have better Children??

Father's age plays a role in the shape, health and form of the children. The study from Austria, suggests that younger the father, better the child's looks.

• Sperm less effectively copies DNA as men age, causes genetic mutation
• 'Errors' in men double every 16 years, women pass same genes at any age
• Follows research men over 45 increase risk of autism by 3.5 times
• Children with older fathers have chromosome construct linked to longevity

Does it Is it back to old days of early marriage and progeny?? Now a days, studies, career are centred on individual's efforts, responsibilities or aspirations; whereas older systems were dependent on the families and communities.

As the system envisaged completion of basic education till at least 16 at a distant places under different Guru, come back to home; continue education and learn responsibilities with practical training.

Marriage and bringing up next generation was the natural responsibility of the grand parents. It had two benefits. 

• Young parents can attend to their works/ education without being affected totally with the infants. 
• When the children grow up, their control would rest with grand parents, who are less aggressive and more affectionate, due to the factors of age and experience.
• Thus the bond between 1st and 3rd Generation would strengthen and old age homes were never thought about, unless the couple is issueless.

Ghee is not harmful to heart

Did you ever hear from your Cardiologists and Trainers warning you, not to consume Ghee, Butter, Cheese or such saturated fats/ oils???

Of late, we have been hearing many appeals from traditional scholars to modern scientists debunking the theory. Now Cambridge University study negates the benefits of Olive Oil, Corn Oil apart from absolving the worsening effects of Saturated Fats. However, some scientists warn us from resumption of uncontrolled consumption.

It is generally agreed that Carbohydrates and Sugars are more dangerous.

Oils are good source for Vitamin E and Ghee is said to be one of the important source for Good Intellect and sharpness. घृतेन वर्धते बुद्धिः। तेजो वै घृतम्।

However, the method of consumption which results in maximum benefit is different from the way we consume today. If practised in the traditional way of consuming fresh ghee with hot food, it could yield desired results.
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Many of us have long been told that saturated fat, the type found in meat, butter and cheese, causes heart disease. But a large and exhaustive new analysis by a team of international scientists found no evidence that eating saturated fat increased heart attacks and other cardiac events.

The new findings are part of a growing body of research that has challenged the accepted wisdom that saturated fat is inherently bad for you and will continue the debate about what foods are best to eat.

For decades, health officials have urged the public to avoid saturated fat as much as possible, saying it should be replaced with the unsaturated fats in foods like nuts, fish, seeds and vegetable oils.

But the new research, published on Monday in the journal Annals of Internal Medicine, did not find that people who ate higher levels of saturated fat had more heart disease than those who ate less. Nor did it find less disease in those eating higher amounts of unsaturated fat, including mono-unsaturated fat like olive oil or poly-unsaturated fat like corn oil.

“My take on this would be that it’s not saturated fat that we should worry about” in our diets, said Dr. Rajiv Chowdhury, the lead author of the new study and a cardiovascular epidemiologist in the department of public health and primary care at Cambridge University.

But Dr Frank Hu, a professor of nutrition and epidemiology at the Harvard School of Public Health, said the findings should not be taken as “a green light” to eat more steak, butter and other foods rich in saturated fat. He said that looking at individual fats and other nutrient groups in isolation could be misleading, because when people cut down on fats they tend to eat more bread, cold cereal and other refined carbohydrates that can also be bad for cardiovascular health.

“The single macronutrient approach is outdated,” said Dr Hu, who was not involved in the study. “I think future dietary guidelines will put more and more emphasis on real food rather than giving an absolute upper limit or cut-off point for certain macronutrients.”

He said people should try to eat foods that are typical of the Mediterranean diet, like nuts, fish, avocado, high-fibre grains and olive oil. A large clinical trial last year, which was not included in the current analysis, found that a Mediterranean diet with more nuts and extra virgin olive oil reduced heart attacks and strokes when compared with a lower fat diet with more starches.

Alice H Lichtenstein, a nutritional biochemist at Tufts University, agreed that “it would be unfortunate if these results were interpreted to suggest that people can go back to eating butter and cheese with abandon,” citing evidence that replacing saturated fat with foods that are high in polyunsaturated fats — instead of simply eating more carbohydrates — reduces cardiovascular risk.

Dr Lichtenstein, who was not involved in the latest study, was the lead author of the American Heart Association’s dietary guidelines, which recommend that people restrict saturated fat to as little as 5 per cent of their daily calories, or roughly two tablespoons of butter or two ounces of Cheddar cheese for the typical person eating about 2,000 calories a day. The heart association states that restricting saturated fat and eating more unsaturated fat, beans and vegetables can protect against heart disease by lowering low-density lipoprotein or so-called bad cholesterol.

In the new research, Dr Chowdhury and his colleagues sought to evaluate the best evidence to date, drawing on nearly 80 studies involving more than a half million people. They looked not only at what people reportedly ate, but at more objective measures such as the composition of fatty acids in their bloodstreams and in their fat tissue. The scientists also reviewed evidence from 27 randomised controlled trials — the gold standard in scientific research — that assessed whether taking polyunsaturated fat supplements like fish oil promoted heart health.

The researchers did find a link between trans fats, the now widely maligned partially hydrogenated oils that had long been added to processed foods, and heart disease. But they found no evidence of dangers from saturated fat, or benefits from other kinds of fats.

The primary reason saturated fat has historically had a bad reputation is that it increases low-density lipoprotein cholesterol, or LDL, the kind that raises the risk for heart attacks. But the relationship between saturated fat and LDL is complex, said Dr. Chowdhury. In addition to raising LDL cholesterol, saturated fat also increases high-density lipoprotein, or HDL, the so-called good cholesterol. And the LDL that it raises is a subtype of big, fluffy particles that are generally benign. Doctors refer to a preponderance of these particles as LDL pattern A.

The smallest and densest form of LDL is more dangerous. These particles are easily oxidized and are more likely to set off inflammation and contribute to the buildup of artery-narrowing plaque. An LDL profile that consists mostly of these particles, known as pattern B, usually coincides with high triglycerides and low levels of HDL, both risk factors for heart attacks and stroke.

The smaller, more artery-clogging particles are increased not by saturated fat, but by sugary foods and an excess of carbohydrates, Dr Chowdhury said. “It’s the high carbohydrate or sugary diet that should be the focus of dietary guidelines,” he said. “If anything is driving your low-density lipoproteins in a more adverse way, it’s carbohydrates.”

While the new research showed no relationship overall between saturated or polyunsaturated fat intake and cardiac events, there are numerous unique fatty acids within these two groups, and there was some indication that they are not all equal.

When the researchers looked at fatty acids in the bloodstream, for example, they found that margaric acid, a saturated fat in milk and dairy products, was associated with lower cardiovascular risk. Two types of omega-3 fatty acids, the polyunsaturated fats found in fish, were also protective. But a number of the omega-6 polyunsaturated fatty acids, commonly found in vegetable oils and processed foods, may pose risks, the findings suggested.

The researchers then looked at data from the randomised trials to see if taking supplements like fish oil produced any cardiovascular benefits. It did not.

But Dr Chowdhury said there might be a good explanation for this discrepancy. The supplement trials mostly involved people who had pre-existing heart disease or were at high risk of developing it, while the other studies involved generally healthy populations.

So it is possible that the benefits of omega-3 fatty acids lie in preventing heart disease, rather than treating or reversing it. At least two large clinical trials designed to see if this is the case are currently underway.

How did the Universe form?

Bicep Experiment supports the theory that tiny atom became a massive universe by INFLATION. 

Theoretical Physics, championed by our seers has their latest pioneers vying for a moment of excitement with the latest discovery about INFLATION. 

This is what myriad sentences of Veda said. For an example - Asad Vaa Idamagra Aaseet. Tato Vai Sadajaayaata; Tadaikshata, Bahu Syaam Prajaayeya etc.

Bicep Experiment supports the theory that tiny atom became a massive universe by INFLATION. 

BICEP (Background Imaging of Cosmic Extragalactic Polarization) is an experiment designed to measure the polarization of the cosmic microwave background (CMB) to unprecedented precision, and in turn answer crucial questions about the beginnings of the Universe.)

BICEP Observatory on South Pole

Why was the telescope positioned on the South Pole??

The team examined spatial scales on the sky spanning about 1 to 5 degrees (two to 10 times the width of the full moon). To do this, they set up an experiment at the South Pole to take advantage of its cold, dry, stable air, which allows for crisp detection of faint cosmic light.

"The South Pole is the closest you can get to space and still be on the ground," said BICEP2 co-principal investigator John Kovac, an associate professor of astronomy and physics at Harvard-Smithsonian Center for Astrophysics, who led the deployment and science operation of the project. "It's one of the driest and clearest locations on Earth, perfect for observing the faint microwaves from the Big Bang."

Stanford physicist Andrei Linde's theory of how universe began

The detection of gravitational waves by the BICEP2 experiment at the South Pole supports the cosmic inflation theory of how the universe came to be. The discovery, made in part by Assistant Professor Chao-Lin Kuo, supports the theoretical work of Stanford's Andrei Linde.

Almost 14 billion years ago, the universe we inhabit burst into existence in an extraordinary event that initiated the Big Bang. In the first fleeting fraction of a second, the universe expanded exponentially, stretching far beyond the view of today's best telescopes. All this, of course, has just been theory.

Researchers from the BICEP2 collaboration today announced the first direct evidence supporting this theory, known as "cosmic inflation." Their data also represent the first images of gravitational waves, or ripples in space-time. These waves have been described as the "first tremors of the Big Bang." Finally, the data confirm a deep connection between quantum mechanics and general relativity.

"This is really exciting. We have made the first direct image of gravitational waves, or ripples in space-time across the primordial sky, and verified a theory about the creation of the whole universe," said Chao-Lin Kuo, an assistant professor of physics at Stanford and SLAC National Accelerator Laboratory, and a co-leader of the BICEP2 collaboration.

These groundbreaking results came from observations by the BICEP2 telescope of the cosmic microwave background – a faint glow left over from the Big Bang. Tiny fluctuations in this afterglow provide clues to conditions in the early universe. For example, small differences in temperature across the sky show where parts of the universe were denser, eventually condensing into galaxies and galactic clusters.

Because the cosmic microwave background is a form of light, it exhibits all the properties of light, including polarization. On Earth, sunlight is scattered by the atmosphere and becomes polarized, which is why polarized sunglasses help reduce glare. In space, the cosmic microwave background was scattered by atoms and electrons and became polarized too.

"Our team hunted for a special type of polarization called 'B-modes,' which represents a twisting or 'curl' pattern in the polarized orientations of the ancient light," said BICEP2 co-leader Jamie Bock, a professor of physics at Caltech and NASA's Jet Propulsion Laboratory (JPL).

Gravitational waves squeeze space as they travel, and this squeezing produces a distinct pattern in the cosmic microwave background. Gravitational waves have a "handedness," much like light waves, and can have left- and right-handed polarizations.

"The swirly B-mode pattern is a unique signature of gravitational waves because of their handedness," Kuo said.

The team examined spatial scales on the sky spanning about 1 to 5 degrees (two to 10 times the width of the full moon). To do this, they set up an experiment at the South Pole to take advantage of its cold, dry, stable air, which allows for crisp detection of faint cosmic light.

"The South Pole is the closest you can get to space and still be on the ground," said BICEP2 co-principal investigator John Kovac, an associate professor of astronomy and physics at Harvard-Smithsonian Center for Astrophysics, who led the deployment and science operation of the project. "It's one of the driest and clearest locations on Earth, perfect for observing the faint microwaves from the Big Bang."

The researchers were surprised to detect a B-mode polarization signal considerably stronger than many cosmologists expected. The team analyzed their data for more than three years in an effort to rule out any errors. They also considered whether dust in our galaxy could produce the observed pattern, but the data suggest this is highly unlikely.

"This has been like looking for a needle in a haystack, but instead we found a crowbar," said co-leader Clem Pryke, an associate professor of physics and astronomy at the University of Minnesota.

Physicist Alan Guth formally proposed inflationary theory in 1980, when he was a postdoctoral scholar at SLAC, as a modification of conventional Big Bang theory. Instead of the universe beginning as a rapidly expanding fireball, Guth theorized that the universe inflated extremely rapidly from a tiny piece of space and became exponentially larger in a fraction of a second. This idea immediately attracted lots of attention because it could provide a unique solution to many difficult problems of the standard Big Bang theory.

However, as Guth, who is now a professor of physics at MIT, immediately realized, certain predictions in his scenario contradicted observational data. In the early 1980s, Russian physicist Andrei Linde modified the model into a concept called "new inflation" and again to "eternal chaotic inflation," both of which generated predictions that closely matched actual observations of the sky.

Linde, now a professor of physics at Stanford, could not hide his excitement about the news. "These results are a smoking gun for inflation, because alternative theories do not predict such a signal," he said. "This is something I have been hoping to see for 30 years."

BICEP2's measurements of inflationary gravitational waves are an impressive combination of theoretical reasoning and cutting-edge technology. Stanford's contribution to the discovery extends beyond Kuo, who designed the polarization detectors. Kent Irwin, a professor of physics at Stanford and SLAC, also conducted pioneering work on superconducting sensors and readout systems used in the experiment. The research also involved several researchers, including Kuo, affiliated with the Kavli Institute for Particle Astrophysics and Cosmology (KIPAC), which is supported by Stanford, SLAC and the Kavli Foundation.

BICEP2 is the second stage of a coordinated program, the BICEP and Keck Array experiments, which has a co-principal investigator structure. The four PIs are Jamie Bock (Caltech/JPL,) John Kovac (Harvard), Chao-Lin Kuo (Stanford/SLAC) and Clem Pryke (UMN). All have worked together on the present result, along with talented teams of students and scientists. Other major collaborating institutions for BICEP2 include the University of California, San Diego; University of British Columbia; National Institute of Standards and Technology; University of Toronto; Cardiff University; and Commissariat à l'Énergie Atomique.

BICEP2 is funded by the National Science Foundation (NSF). NSF also runs the South Pole Station where BICEP2 and the other telescopes used in this work are located. The Keck Foundation also contributed major funding for the construction of the team's telescopes. NASA, JPL and the Moore Foundation generously supported the development of the ultra-sensitive detector arrays that made these measurements possible.

Technical details and journal papers can be found on the BICEP2 release website:http://bicepkeck.org

Reaction of the Russian Theoretical Physicist Prof. Andrei Linde, who is the Founding father of the Gravitational Waves INFLATION Theory, when the news broke by Prof Kuo.

http://www.forbes.com/sites/matthewherper/2014/03/18/the-most-heartwarming-moment-from-yesterdays-groundbreaking-physics-discovery/

Vitamins - History

Carl Zimmer, explains the history of Vitamins and their composition and necessity. Incidence of Scurvy Disease among sailors led to the discovery of Vitamin C.

What is the history behind vitamins? And how did we come to realise that these nutrients are vital for us? Carl Zimmer takes us through its story and reveals the intricacies involved.
In 1602, a Spanish fleet was sailing up the Pacific coast of Mexico when the crew became deathly ill. “The first symptom is pain in the whole body that makes it sensitive to touch,” wrote Antonio de la Ascensión, a priest on the expedition. “Purple spots begin to cover the body, especially from the waist down; then the gums become so swollen that the teeth cannot be brought together, and they can only drink, and finally they die all of a sudden, while talking.”

The crew was suffering from scurvy, a disease that was then both bitterly familiar and deeply mysterious. No one knew why it struck sailors or how to cure it. But on that 1602 voyage, Ascensión witnessed what he considered a miracle. While the crew was ashore burying the dead, one sick sailor picked up a cactus fruit to eat. He started to feel better, and his crewmates followed his example.

“They all began to eat them and bring them back on board so that, after another two weeks, they were all healed,” the priest wrote.

Over the next two centuries, it gradually became clear that scurvy was caused by a lack of fruits and vegetables on long-distance voyages. In the late 1700s, the British navy started supplying its ships with millions of gallons of lemon juice, eradicating scurvy. But it wasn’t until 1928 that Hungarian biochemist Albert Szent-Gyorgyi discovered the ingredient that cured scurvy: Vitamin C.

Szent-Gyorgyi’s experiments were part of a wave of early-20th-century research that pulled back the curtain on vitamins. Scientists discovered that the human body required minuscule amounts of 13 organic molecules. A deficiency of any of the vitamins led to different diseases - a lack of vitamin A to blindness, vitamin B12 to severe anaemia, vitamin D to rickets.

Today, a huge amount of research goes into understanding vitamins, but most of it is focused on how much of them people need to stay healthy. This work does not address a basic question, though; How did we end up so dependent on these peculiar little molecules?

Recent research is providing new answers. It appears that vitamins were essential to life from its earliest stages some 4 billion years ago. Early life-forms could make their own vitamins, but some species - including ours later lost that ability. Species began to depend on each other for vitamins, creating a complex flow of molecules that scientists have named “vitamin traffic.”

A universal chemistry

Every vitamin is made by living cells – either our own, or in other species. Vitamin D is produced in our skin, for example, when sunlight strikes a precursor of cholesterol. A lemon tree makes vitamin C out of glucose. Making a vitamin is often an enormously baroque process. In some species, it takes 22 proteins to craft a vitamin B12 molecule.

While a protein may be made up of thousands of atoms, a vitamin may be made up of just a few dozen. And yet, despite their small size, vitamins expand our chemical versatility. A vitamin cooperates with proteins to help them carry out reactions they couldn’t manage on their own. Vitamin B1, for example, helps proteins pull carbon dioxide from molecules.

Vitamins carry out these chemical reactions not just in our own bodies but in all living things. 

The ability we lost

Once the ability to make vitamins evolved, some species became especially good at making them. Plants, for example, evolved into vitamin C factories, packing their leaves and fruits with the molecule. At first, vitamin C probably defended plants against stress – a function it carries out in other species, including us. But over time, the vitamin took on new jobs in plants, like helping control the development of fruit.
Many vertebrates can make vitamin C, and use an identical set of genes to do so. “We should be able to make it, too, since we have all the genes,” said Rebecca Stevens of the French National Institute for Agricultural Research.

Unlike a frog or a kangaroo, however, we have crippling mutations in one of those genes, known as GULO. Unable to make the GULO protein, we cannot produce vitamin C.

“It’s not just us – it goes back a long time,” said Guy Drouin, a molecular evolutionary biologist at the University of Ottawa. He and other researchers have found that apes and monkeys, our closest primate relatives, have disabled GULO genes, with many of the same mutations. Drouin has concluded that the common ancestor we share with those other primates lost the ability to make vitamin C around 60 million years ago.

It wasn’t just us

Now that scientists can scan genomes of thousands of species, they’re discovering many more cases in which vitamin genes have either decayed or disappeared altogether. Sergio Sanudo-Wilhelmy of the University of Southern California and his colleagues recently surveyed the genomes of 400 of the most abundant species of bacteria in the oceans. As they report in a paper to be published in the Annual Review of Marine Science, 24 percent of the bacteria lack genes to make B1, and 63 percent can’t make B12.

These recent studies are especially surprising because bacteria have long been considered self-sufficient when it comes to vitamins. Now scientists need to figure out why many species of bacteria in the ocean aren’t dead from a microbial version of scurvy.

Only recently have scientists made measurements of vitamins in the sea. They are finding some places that are abundant with them and others that are vitamin deserts. It is possible that the difference influences not just bacteria and algae, but the animals that feed on them.

Vitamins flow in complex routes, not just in the ocean, but on land. We humans can’t make our own supply of vitamin B12, for example, so we need to get it from food. One way is to eat meat like beef, which contains B12. It turns out that the cows and other animals that we consume don’t make B12 in their own cells. Instead, the bacteria in their guts manufacture it for them.

We are also home to thousands of species of bacteria, which synthesise vitamins as they eat our food. Does that mean we depend on our internal vitamin traffic? “It’s still theoretical,” said Douwe van Sinderen, a microbiologist at University College Cork in Ireland. “But evidence is building that bacteria can provide some vitamins that we need.”

If that’s so, we may need to think of our bodies as self-contained oceans of vitamin traffic – a continuation of the traffic that has occurred on Earth for 4 billion years.